Surface Science Blog

Protein Aggregation in Neurodegenerative Diseases

Posted by Fredrik Andersson on December 8, 2015

Proteins are vital for life and perform a wide range of essential biochemical tasks in all living organisms. Cells of these organisms are hence under a constant pressure to maintain an optimal protein environment, assuring all proteins are correctly folded and functional.

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Topics: Protein Adsorption, Protein Aggregation

How surface roughness and wettability affects biocompatibility

Posted by Anna Oom on November 24, 2015

Various types of artificial materials are being utilized as implants in all fields of medicine. The surface properties of the implant determine its interactions with the surrounding host tissue. Physicochemical properties of the surface, like wettability and surface roughness, are of prime importance for the optimization of adhesion, spreading and proliferation of cells.



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Topics: Biomaterials, Wettability, Surface Roughness, Protein Adsorption, Adhesion, Surface Free Energy

Protein Adsorption to Biomaterials

Posted by Gunilla Rydén on July 14, 2015

Blood-material interactions are critical for the performance and biocompatibility of implantable medical devices used in thousands of patients everyday. When a biomaterial is introduced into the body, protein adsorption and activation of complement proteins occur. Complement proteins are mediators of inflammation, and are therefore of interest in biomaterials research. Success often depend on interactions between the biomaterial’s surface and its physiological environment. Modifications are often made to the surface of biomaterials to modulate their physical and chemical properties in order to improve the functionality of the biomaterial in a given application.

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Topics: Biomaterials, Protein Adsorption