Gabriel Ohlsson Feb 12, ’19 ~ 3 min

How to measure polymer brush swelling and collapse

 

Polymer brushes, polyelectrolyte multilayers and hydrogels are typically used to achieve desirable properties such as biocompatibility, antifouling properties and drug delivery capabilities. Layer conformation and the degree of hydration are key parameters influencing the interfacial properties. Here we show a straightforward way to measure the transitions between hydrated and dehydrated states i.e. the swelling and collapse.

Real-time characterization of polymer brush swelling and collapse

The transition between hydrated and dehydrated states of polymer brush layers and other thin films can be assessed by for example QCM-D, which will sense the water uptake and release as changes in mass.

As an example, the swelling and collapse of polymer brushes made of chitosan have been analyzed with QCM-D. The conformation of the chitosan brush depends both on pH and counter-anion size. At low pH, the brush is water-soluble while at pH above 6.5, it is a collapsed coil and insoluble in water.

In this experiment, chitosan was grafted onto the QCM-D sensors. The brush layer was then exposed to solutions of different pH and counter-anion size while the layer thickness was measured. 

The results of the measurement are shown in Fig. 1. Looking at the plot, it is noted that the layer swells at low pH and contracts at high pH. It is also noted that the transition between the swollen and collapsed states are reversible and that the larger counter-anions induce more swelling than the smaller counter-anions.

Thin film swelling and collapse

Figure 11. The graph shows how the thickness of the chitosan brush varies when exposed to solutions of different pH and counter-anion type. The brush swells at low pH and contracts at high pH.

Concluding remarks

To tailor the interfacial properties of polymer-based materials, such as polymer brushes, so that they support the desired interaction with the environment, the structure and structural changes of the layer must be characterized. Such characterization is straightforward with for example QCM-D, which detects changes in the degree of hydration and transitions between swollen and collapsed states.  

Download the application note to read the full study.

Application note  Characterization of polymer layer swelling crosslinking and collapse  Download

References:

  1. H-S Lee, et al., J. Mater. Chem., 22, 19605, 2012

1Figures are reproduced from Ref. 1 with permission from The Royal Society of Chemistry.

Cover photo by Samara Doole on Unsplash

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